Osteoarthritis is a disease that occurs frequently in humans and companion animals.
Literature shows clearly that the molecules involved in OA of humans andcompanion animals are essentially the same molecules.
This prompted Orthros to evaluate whether these molecules have a high degreeof homology and that turns out to be the case. Below a summary of this research. We found that often these molecules have large stretches of amino acids that are identical. Because of that high degree of homology we can select from the manyimmune libraries QVQ and Orthros have created, those VHH that recognize not only the human form of a target but also those for dogs, cats and dogs.
Therefore Orthros will follow the sequence of analyses of newly selected VHH.
We will perform tests on:
binding, cell systems of humans and dogs, functionality in experimental animals, adaptation of the selected VHH to the immune systems of humans and dogs, safety studies of these adapted VHH, treatment of dogs with OA with the selected VHH.
The next step will be production under GMP conditions and Micro-dosingstudies in humans.
For more detailed info of Orthros’ Technology, view this presentation.