Millions of companion animals suffer of Osteoarthritis. Just as for humans no effective therapy exists to treat these animals. Using the large data bases of DNA and proteins of humans and companion animals Orthros found that there is an unexpected high degree of identity [of stretches of amino acids in] molecules involved in Osteoarthritis.
Orthros has based on these analyses developed a strategy to select VHH that show cross reactivity between humans, dogs, horses and cats of over 20 Osteoarthritis. This will enable Orthros to develop VHH, Anchorbodies or Sinkbodies that can be used in animal patients and with no or minor changes later on in humans with Osteoarthritis.