A new way to combat osteoarthritis: with Llama antibodies
Human & Dog Joint Similarities
Orthros Medical focusses on the development of medicine against Osteoarthritis for human but also for companion animals. Pets also suffer from Osteoarthritis, there are over 5 million dogs suffering from Osteoarthritis and Orthros wants to help. Dogs and many other animals have very similar morphology as humans. The joints and bones of dogs for example are tissues that are almost identical in composition and structure as human.
Decreasing inflammation with anti-IL-1 receptor VHH
Orthros is working on a VHH molecule that should decrease inflammation. Inflammation is caused by the cytokine molecule called “Inter Leukin-1” (IL-1). By blocking the pathway of IL-1 with anti-IL-1 receptor VHH, other cytokines and MMPs that promotes inflammation does not get produced. Although inflammation does not play as big of a role as in Rheumatoid Arthritis it is the main cause of joint swelling, joint pain, joint stiffness or even loss of joint function, all symptoms present in Osteoarthritis.